The main focus of research is the study of nucleotide receptor signalling in the central nervous system and its role in processes such as neuronal survival, differentiation, and regeneration. Nucleotides regulate a wide variety of functions by activating ionotropic (P2X) and metabotropic (P2Y) receptors that are ubiquitously distributed in different populations of neurons and astrocytes. Recent work has described the neuroprotective role of P2X7 and P2Y13 receptors in these neural models against different apoptotic stimuli, and enhancing the protective effects of neurotrophic factors, such as BDNF, by virtue of their coupling to different signalling proteins, MAP kinases, and GSK3. This signalling is also involved in the transcriptional regulation of the P2X7 receptor. A new line of research of the group focuses on the regulatory mechanisms of adult neurogenesis and the involvement of purinergic receptors in this process.
Degree (1982) and PhD in Biology with Extraordinary Prize (1987) from the University of Murcia. She is currently Professor of Biochemistry and Molecular Biology at the Complutense University of Madrid.
She started her research career as a student intern at the Interfaculty Department of Biochemistry of the University of Murcia, where she completed her thesis under the supervision of Dr. Juan Carmelo Gómez Fernández, and most of the experimental work for her doctoral thesis, thanks to a grant from the FIS. In 1986 he moved to the Faculty of Veterinary Medicine of the Complutense University of Madrid together with his thesis supervisor, Dr. Mª Teresa Miras Portugal, where he has developed his entire teaching and research career.
Her research has focused on the study of different stages of extracellular nucleotide-mediated signalling. She contributed to the characterisation of the nucleoside transporter in different neural models, a key step in the recovery of intracellular levels of adenosine, the end product of extracellular nucleotide hydrolysis. Studies in chromaffin cells showed that the facilitated diffusion transporter (SLC29) was regulated by phosphorylation-dephosphorylation processes as was later demonstrated for other neurotransmitter transporters. In recent years, the research line has mainly focused on the study of nucleotide receptors and their implications in neuroprotection processes in order to identify new therapeutic targets.
He has participated in more than 30 national and European research projects.
He has supervised 9 doctoral theses and numerous dissertations and dissertations.
Total publications: 58 h-index: 23.74. Total citations: 1,377 (WOS).
Six-year research periods awarded: 5 (last six-year period: 2011-2016).
Five-year teaching periods awarded: 6.
ORCID code. 0000-0001-6281-0816.
Research ID: L-6992-2014.