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Inﬂammation, Infection, Immunity and Allergy
Kidney Diseases and Renal Function Replacement Therapy (Dialysis and Transplantation)

Kidney Diseases and Renal Function Replacement Therapy (Dialysis and Transplantation)

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PRINCIPAL INVESTIGATOR

Ana Isabel Sánchez Fructuoso
asanchez.hcsc@salud.madrid.org
Tel. +34 913303000 (Ext. 482106)
ADDRESS

Nephrology Service

San Carlos Clinical Hospital
Profesor Martín Lagos s/n 28040 Madrid

Group information

All areas of the Nephrology Department actively participate in trials and studies on chronic kidney disease, diabetic nephropathy, glomerular, systemic, and vascular diseases, renal transplantation, and haemodialysis. This research is inseparable from the healthcare activity carried out in this Department and is performed both with its own projects and with multicentre studies with public and private funding. To this end, we collaborate with other hospital services and the Faculty of Medicine of the Complutense University of Madrid.

Strategic objectives

STRATEGIC OBJECTIVES OF THE TRANSPLANTATION UNIT

To deepen the study of new immunosuppressive therapies.
To promote genetic testing in the field of renal transplantation.
To enhance individualisation of immunosuppression in renal transplantation
To improve the quality of life of transplanted patients from both asystole and brain-dead donors.

STRATEGIC OBJECTIVES OF THE DIALYSIS UNIT

To improve dialysis adequacy in both HD and PD.
To prolong the functioning of vascular access in HD.
To apply the most effective technique with the least anticoagulation side effects in the HD session.
To improve the nutritional status of dialysis and ACKD patients.
To establish prognostic markers of SARS-CoV-2 infection in dialysis and ACKD.

STRATEGIC OBJECTIVES OF THE CLINICAL NEPHROLOGY UNIT

To further develop new diagnostic and therapeutic strategies in glomerular pathology.
To slow down the progression of diabetic kidney disease in line with the use of new therapies. To promote research on nephroprotection beyond diabetic kidney disease for these new therapies.
To strengthen, promote, and study new therapeutic uses of drugs with renal involvement.
To study renal pathology associated with cancer: epidemiology, diagnosis, and new therapeutic tools.

Lines of research

LINES OF RESEARCH LINKED TO THE STRATEGIC OBJECTIVES OF THE TRANSPLANT UNIT

To analyse those factors that may have the greatest influence on short- and long-term graft survival.
To identify the best parameters to provide information on the functional status of the transplanted organ.
To search for biomarkers to help us establish the right balance between appropriate immunosuppression therapies and a controlled immune response against the graft.
Kidney transplantation and SARS-CoV2 infection

LINES OF RESEARCH LINKED TO THE STRATEGIC OBJECTIVES:

To explore dialysis techniques and procedures to reduce protein-bound toxin concentrations in dialysis and ACKD patients.
To analyse and implement methods to improve the detection and treatment of HD vascular access dysfunction.
To identify the most efficient techniques for anticoagulation of the HD circuit.
To identify the best methods for the diagnosis, staging and treatment of malnutrition in HD, PD, and ACKD.
To determine the value of plasma D-Dimers in SARS-CoV-2 infected patients on ACKD and dialysis.

LINES OF RESEARCH LINKED TO THE STRATEGIC OBJECTIVES:

Participation in multicentre studies of glomerular pathology, notably:
- Epidemiology, histopathology, and evolution of fibrillary glomerulonephritis in our environment.
- Study of predictors of renal relapse in lupus nephritis.
Analysis of the use of ISGLT2 in patients with non-diabetic kidney disease.
Nephrotic syndrome as a paraneoplastic entity.
Histopathology in patients with cancer and renal disease.
Analysis of the evolution of immune-mediated nephritis secondary to checkpoint inhibitors: therapeutic strategies.