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Molecular and Epidemiological Study of Resistant Microorganisms of Clinical Interest

Molecular and Epidemiological Study of Resistant Microorganisms of Clinical Interest

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PRINCIPAL INVESTIGATOR

Delgado‐Iribarren García‐Campero, Alberto
adelgadoi@salud.madrid.org
Tel. +34 913303000 (Ext. 484707)
ADDRESS

HCSC Microbiology Service

San Carlos Clinical Hospital
C/ Profesor Martín Lagos s/n 28040 Madrid

Group information

Multidisciplinary training group (physicians, pharmacists, and biologists) focused on the study of infectious diseases from the interrelationship between microorganisms and human beings, with special attention to the epidemiology, pathogenesis, diagnosis, and therapeutic opportunities of those that present resistance to antimicrobials.

All members of the research team have been working in this field for years, including epidemiological monitoring of certain infection-producing strains, the evolution of their susceptibility to certain antibiotics, the molecular mechanisms involved in cases of resistance, and treatment options for new molecules. This group also has accredited experience in the handling of pathogenic micro-organisms and the usual techniques for their diagnosis and study. The group has publications to support this work and has had several projects funded by both public and private money. Several doctoral theses have been completed and are currently in progress.

The year 2020 has led us to develop multiple molecular microbiology assays and to develop new lines of research, which are described below. Much of the work being developed is carried out in collaboration with other research groups (Regional Public Health Centre, Complutense University of Madrid, National Microbiology Centre and other National Health System Hospitals).

Review

Dr. Alberto Delgado-Iribarren García-Campero has a degree in Medicine and Surgery and a PhD in Pharmacy (UCM); Specialist in Microbiology and Parasitology (No. 1 in the 1984 FIR exam). Diploma in Clinical Research Methodology (C. Universitario de Salud Pública).

Currently Head of the Microbiology and Parasitology Department at the Hospital Clínico San Carlos in Madrid. Formerly Head of the Microbiology and Parasitology Service and President of the Infection Commission Antibiotic Policy and Prophylaxis of the Fundación Hospital Alcorcón. From 2008 to 2009 Coordinator of the Microbiological Ring of the New Hospitals of Madrid (S.Sebastián de los Reyes, Coslada, Arganda, Vallecas, Parla and Aranjuez).

Currently collaborating in 10 research projects. More than 100 publications related to Clinical Microbiology and Infectious Diseases. Participated in numerous clinical and research trials.

Strategic objectives

To enhance national collaborations and promote international ones by joining networks, consortia, and study groups.
To promote translational research results in clinical practice for patients and society.
To participate in innovation projects with interdisciplinary teams.
To advise Health Authorities, Reference Centres, and companies in the sector on the validation and development of new diagnostic techniques, or antimicrobials.
To increase the visibility and impact of the group’s results, and for these results to be used as an incentive for the members’ own professional development.
To encourage the research activity of new residents and colleagues with related interests, and undergraduate students.

Lines of research

Study, monitoring, and evolution of the levels of resistance of the most prevalent pathogenic bacteria, or those with the greatest clinical impact to the antibiotics used for their treatment. Study of the evolution of the type of carbapenemases isolated from enterobacteria in colonised patients. Analysis of samples collected from children with invasive pneumococcal disease to assess effectiveness of pneumococcal vaccine.
Study of resistance mechanisms, genes involved, and dissemination capacity among pathogenic bacteria in our environment. Identification and study of clonal clusters endemic to or responsible for outbreaks of infectious diseases, in particular, multi-resistant micro-organisms.
Study of the clinical and epidemiological characteristics and therapeutic options of invasive fungal infections, in particular, candidaemia.
Control, monitoring, and improvement strategies in the clinical management of patients with imported parasitosis, especially Chagas disease. Effectiveness in reducing mother-to-child transmission of Chagas disease through a screening programme in pregnant women. Reintroduction of benznidazole
Clostridioides difficile infection and the importance of diagnostic interpretation and impact of recurrences in clinical practice. Evolution of Sexually Transmitted Infections (STI) in the area of influence of the HCSC.
Study and follow-up of the immunity generated by the different SARS-CoV-2 vaccines available in the Community of Madrid, including nursing home patients.
NGS sequencing analysis of emerging pathogens including SARS-CoV-2. The role of the microbiome and resistome in infectious pathology.
Study on cell-mediated immunity in people exposed to SARS-Cov2 and after vaccination.