Environmental Factors in Degenerative Diseases

Strategic objectives

  • To investigate the possible mechanisms by which herpes viruses could be involved in the aetiopathogenesis of different degenerative diseases, and their interaction with possible genetic factors of susceptibility to these diseases, by analysing viral loads, antibody titres, and expression of viral microRNAs.
  • Study of the mechanisms involved in the reactivation of JC virus, the causative agent of progressive multifocal leukoencephalopathy.
  • Analysis of vitamin D as a possible modulator of the immune system and the genetic factors associated with its levels and with its activation and degradation processes.
  • Study of human endogenous retroviruses (HERVs) as genetic and environmental factors involved in the development of different degenerative diseases.
  • Analysis of circulating metabolites produced by the gut microbiota and their interaction with the immune system and/or the central nervous system in patients with degenerative diseases.

Lines of research

  • Identification of environmental factors involved in the triggering and progression of degenerative diseases.
  • Study of gene-environment interaction in degenerative diseases.
  • Optimisation of molecular biology techniques applied to the study of the different environmental factors associated with degenerative diseases.

Other members of the group

  • Enara Cuadrado Regil
  • María Inmaculada Domínguez Mozo
  • María Ángel García Martínez
  • Isabel Ortega Madueño
  • Carla Rodríguez García
  • María José Torrejón Martínez