Clinical and Neurobiological Research In Psychiatry and Mental Health

Strategic objectives

  • Study of genetic markers of vulnerability in schizophrenia and their biological functionality: Study of its protein expression
  • Characterisation of the ANKK1 gene in relation to dopaminergic function
  • Relationship between genetic/molecular vulnerability factors and neurophysiological, neuropsychological, and functional neuroimaging variables
  • Study of the implication of immune system functioning in vulnerability to schizophrenia and depression
  • Study of the mediators involved in the process of neuroinflammation in schizophrenia and depression
  • Comparative analysis between schizophrenia and bipolar disorder: Genetic/molecular factors, Cognitive function, Neurophysiological variables, Brain activation to neuropsychological tasks and restingstate analysis
  • Study of the evolution of schizophrenia from the first psychotic episodes to the advanced stages of the disease
    • Genetic variables. Genes of the dopaminergic system and other related systems Epigenetics. Gene/environment interaction (toxics)
    • Immunological and neuroinflammatory markers: immune response mediators, transcription factors, HHA axis mediators, and enzymatic activity
    • Cognitive function. Evolution of cognitive function
    • Changes according to the evolution of the disorder in P50.P300 and IPP
  • Functional neuroimaging. Studies of activation to cognitive tasks; and connectivity analysis (DTI), restingstate
  • Study of the influence of substance use disorders on the etiopathogenesis of psychosis, evolution, cognitive functioning, neurophysiological responses, and functional neuroimaging
    • Study of neurodegeneration in schizophrenia, by neuroimaging analysis, and study of the associated genetic, epigenetic, and environmental factors
  • Studies of markers of neuroinflammation in relation to vulnerability to different psychiatric disorders, both in animal models and in patients
    • Study of the pathophysiological mechanisms and pharmacological basis of stress-induced brain damage processes, in view of the relationship between stress exposure and numerous neuropsychiatric pathologies
    • Identification of possible new therapeutic targets and evaluation of neuroprotective strategies in the aforementioned processes
  • Utility of clozapine use in first psychotic episodes: clinical evolution, cognitive evolution, and neuroimaging analysis
  • Identification of areas of intracranial stimulation with therapeutic value in obsessive-compulsive disorder, and other treatment-resistant psychiatric illnesses
  • Development of stigma prevention programmes on psychiatric illness in the health care setting
  • Establishment of a programme for the prevention of sequelae of psychological trauma in disasters and catastrophes
  • To study the impact of schizophrenia on the individual’s health status, psychosocial adjustment, quality of life, levels of disability, and patterns of service utilisation and its influence on co-morbidity
  • Contribution to the development of a clinical staging system for depressive disorders and schizophrenia

Lines of research

  • Molecular and genetic basis of neuropsychiatric disorders
  • Genetic/molecular and environmental vulnerability to schizophrenia
  • Evolution of schizophrenia: first psychotic episodes. Neurodegeneration
  • Addictive Disorders, psychosis and dual pathology
  • Comparative cognitive, genetic, neuroimaging and neurophysiological study of schizophrenia and bipolar disorder
  • Study of neuroinflammation as an aetiopathogenic factor in mental illness. Stress study
  • Molecular neuropsychopharmacology. The search for biomarkers and new therapeutic targets
  • Treatment of schizophrenia at different stages
  • Neuromodulation, connectivity, and the neurobiological basis of psychiatric disorders
  • Neurocognitive research in obsessive-compulsive spectrum disorders and other psychiatric illnesses
  • Research on factors involved in the stigma of mental illnesses
  • Research on preventive factors and early intervention in post-traumatic stress disorder and psychological trauma
  • A study of staging as a paradigm for the prevention, progression, and treatment of mental illness
  • Psychiatric morbidity in medical-surgical patients. Population psychiatric morbidity and healthcare resource utilisation
  • Ageing and Dementia

Other members of the group

  • Anna Aguilar Palacios
  • Isabel María Argudo Carpel
  • Julia María Del Rio Vega
  • Diego Figuera Álvarez
  • David Fraguas Herraez
  • Filiberto Fuentenebro De Diego
  • Jose Antonio Gallastegui Galan
  • Lucía Gallego Deike
  • Marta García Huescar
  • Julia García-Albea Martín
  • María Inés López-Ibor Alcocer
  • Rosa María Molina Ruíz
  • Laura Oca Bravo
  • Mª Del Rosario Pérez Moreno
  • Antonio Pelaz Antolín
  • Mª Isabel Ramos García
  • María Dolores Saiz González
  • Beatriz Serván Rendon-Luna
  • Julia Sevilla Llewellyn-Jones
  • Nuria Tur Salamanca
  • Maria Luisa Zamarro Arranz

Publications

Projects