Endocrinology of Metabolic Diseases

+ Info

PRINCIPAL INVESTIGATOR

Alfonso Calle Pascual
alfonsoluis.calle@salud.madrid.org
Tel. +34 913303000 (Ext. 483127)
Miguel Angel Rubio Herrera
ADDRESS

Endocrinology and Nutrition

1ªS. San Carlos Clinical Hospital
C/ Profesor Martín Lagos s/n. 28040 Madrid

Group information

The Endocrinology of Metabolic Diseases research group is seen as an organisational element designed to facilitate applied research based on clinical management and integrated care for endocrinology patients with metabolic diseases.

It shall encourage the participation, involvement, and exercise of responsibility of all its professionals. It will use advanced information systems as an element of cost-effectiveness and quality assessment in translational research in metabolic diseases.

It will be involved in the control of the efficiency of the research that will be carried out through the highest management bodies of the Centre or, where appropriate, of the Health Centres, whose fundamental mission is to increase knowledge for the prevention and treatment of all metabolic diseases in the field of Endocrinology and Nutrition.

Strategic objectives

Epidemiology of diabetes mellitus and its complications. Registry of amputations of non-traumatic origin in patients with diabetes (GLEAs Registry). Modifiable factors associated with the onset of type 2 DM in Spain (estudio di@bet.es)
Influence and characterisation of lifestyle on the prevention and treatment of diabetes mellitus and associated metabolic diseases. Prevention of the onset of type 2 diabetes and associated metabolic diseases in women who have had gestational diabetes. Regression of newly diagnosed type 2 diabetes. Analysis of modifications of gastrointestinal hormone- and neuropeptide-mediated signalling in appetite control mechanisms. Activity and expression of 11-beta-hydroxy-steroid dehydrogenase 1 in liver and adipose tissue (subcutaneous and visceral) of morbidly obese patients and its relationship with metabolic syndrome.
Characterisation of inflammation and oncogenesis in metabolic diseases. Pharmacogenetics of somatostatin analogues in patients with gastroenteropancreatic neuroendocrine tumours: study of polymorphisms, somatic mutations, and proteins involved in tumour response.
Regulation of body weight in obesity by analysis of gastrointestinal hormones and coding genes.
Implication of bariatric surgery in the treatment of morbid obesity and remission of diabetes mellitus.
Expression of genes involved in glycogenic/lipogenesis pathways in individuals with/without metabolic syndrome.
Development of therapeutic optimisation protocols in clinical nutrition.

Lines of research

Epidemiology of diabetes mellitus and its complications.
Influence and characterisation of lifestyle on the prevention and treatment of diabetes mellitus and associated metabolic diseases.
Characterisation of inflammation and oncogenesis in metabolic diseases.
Obesity, bariatric surgery, and body weight regulation
Diabetes, metabolic syndrome, metabolic surgery
Molecular biology linked to obesity, diabetes, vascular risk, and cancer
Clinical Nutrition