Diabetes and Cardiovascular

Strategic objectives

  • Role of compensatory mechanisms of insulin resistance in relation to vascular injury.
  • Role of a hepato-pancreatic endocrine axis in the development of pancreatic beta-cell hyperplasia in response to insulin resistance in the liver.
  • Role of the thermogenic function of brown adipose tissue in relation to the control of energy balance.
  • Mechanisms of insulin resistance in cardiovascular cells mediated by pro-inflammatory and macrovascular injury signals

Lines of research

Molecular mechanisms in the progression of type II diabetes

  • To study the role of the TSC2/mTORC1 complex, autophagy and reticulum stress in the control of pancreatic beta-cell expansion and failure using in vitro and in vivo models.
  • Determine the role of human amylin in the progression to type 2 diabetes using in vitro and in vivo models, as well as the connection between type 2 diabetes and neurodegeneration.
  • To analyse the elimination of protein aggregates and/or altered organelles by using plant extracts through the potentiation of autophagy.
  • To study the role of different modulators of signalling pathways involved in ageing (SIRT1, AMPK, mTOR) and progression to diabetes.

Thermogenic function and inflammatory adipose organ disease

  • New murine models of brown adipose tissue thermogenic dysfunction: tissue-specific BATIGFIRKO and BATIGFIRDKO.
  • Role of mitochondrial dynamics and mitophagy in the control of adaptive thermogenesis: New murine models of brown adipose-specific BAT Opa-1 and BAT MFN-1 KOs.


Other members of the group

  • Manuel Roman Benito De Las Heras
  • Silvia Fernández López
  • Ana García Aguilar
  • Gema García Gómez
  • Carlos González Blanco
  • Elena Gonzalez Trujillos
  • Olga María Palomino Ruiz-Poveda