Clinical and Translational Research in Oncology

Strategic objectives

The following institutions will be eligible for financing through the ISCIII:

  • Development and maintenance of the clinical trials platform (Phases I, II, and III).
  • To continue to be a reference unit in the analysis of susceptibility and range genes in
  • the most common tumours.
  • To consolidate the platform of prognostic and predictive biomarkers of therapeutic targets in
  • colon cancer.
  • To consolidate the CTC (circulating tumour cell) platform in breast and colon cancer, and
  • To develop it in other tumours such as lung and prostate.
  • To continue to be a leading group within the Research Network of Cancer Centres (RTICC) of the Instituto Carlos III.

Lines of research

  • Identification of predictive response factors and new therapeutic targets in colon, breast, glioma, and prostate cancer and design and analysis of the efficacy of new therapies in preclinical models of these tumours.
  • Pharmacogenomic study of predictive factors of response and toxicity in colon, breast, and lung cancer. Analysis of global gene expression. Study of molecular pathological, pharmacodynamic, and pharmacogenetic determinants.
  • Liquid biopsy and biomarkers: a) Biomarkers in liquid biopsy (circulating nucleic acids, circulating tumour cells, vesicles) in cancer patients. Potential use as non-invasive prognostic and predictive biomarkers; b) Mechanistic analysis of circulating nucleic acids in vesicles in the tumour environment, and their influence on tumourigenic processes.
  • Molecular mechanisms of genetic susceptibility to cancer (breast-ovarian syndrome and Lynch syndrome).
  • Microarray and microRNA platform.

Other members of the group

  • Sandra Abella Falgueras
  • Carlos Aguado De La Rosa
  • María Del Rosario Alfonso San Segundo
  • Emilia Alors Pérez
  • Inmaculada Bando Polaino
  • Julia Barrios Barriga
  • Jorge Bartolomé Arcilla
  • Inés Bartolomé Asensio
  • Javier David Benitez Fuentes
  • Santiago Cabezas Camarero
  • Susana Campuzano Ruiz
  • Laura Carrasco Sánchez
  • Antonio Casado Herráez
  • Marco Ciappara Paniagua
  • Belén Cobaleda Esteban
  • Ana Conde Yáñez
  • Juan Antonio Corona Sánchez
  • Cristina Díaz-Tejeiro Rodríguez
  • Miguel De La Hoya Mantecón
  • Paula Diaque García
  • Ana Esteban Garcimartín
  • Ada Esteban Sánchez
  • Gonzalo Fernández Hinojal
  • Lorena Fernandez Montarroso
  • Carlos Alfredo Fraile Olivero
  • Jesús Fuentes Antrás
  • Alicia Gómez Sanz
  • María Elena Gómez Del Pulgar Gutiérrez
  • Mª Isabel Galante Romo
  • Laura García Bravo
  • Vanesa García Barberán
  • Beatriz García Paredes
  • José Ángel García Sáenz
  • Gabriel Garcia Salamero
  • Pilar Garre Rubio
  • Juan Gomez Rivas
  • José Luís González Larriba
  • Alicia Herance Blasco
  • María Helena Huertas Mondejar
  • Igor Gregorio López Cade
  • Miguel López García
  • Víctor Lorca Castellanos
  • Tania Luís García
  • Aránzazu Manzano Fernández
  • Gloria Marquina Ospina
  • Miquel Martínez Fontanillas
  • Ana Martínez Rodríguez
  • Jesús Moreno Sierra
  • Fernando Moreno Antón
  • Ignacio Moreno Pérez
  • Luisa Morillas Perruca
  • Cristina Nieto Jiménez
  • Alberto Ocaña Fernandez
  • Helena Olivera Pérez-Frade
  • Alberto Orta Ruiz
  • Natalia Pérez Romero
  • Beatriz Pérez-Villamil Salgado
  • Lucía Paniagua Herranz
  • Daniel Parra Corral
  • Jose Manuel Pingarron Carrazon
  • Javier Puente Vázquez
  • Sara Rafael Fernández
  • Lobna Ramadane Morchadi
  • Enrique Redondo Gonzalez
  • Sandra Rico Galve
  • Raquel Rodríguez Damiano
  • Teresa Salas García-Talavera
  • Jesús María Salinas Casado
  • Adrián Sanvicente García
  • Javier Sastre Valera
  • Jose Luis Senovilla Perez
  • Alvaro Serrano Pascual
  • Laura Torresano Cicuéndez
  • Manuel Gonzalo Vázquez Masedo
  • Marta Vidaurreta Lázaro

Publications

Projects