Clinical and Translational Research in Oncology

Strategic objectives

The following institutions will be eligible for financing through the ISCIII:

  • Development and maintenance of the clinical trials platform (Phases I, II, and III).
  • To continue to be a reference unit in the analysis of susceptibility and range genes in
  • the most common tumours.
  • To consolidate the platform of prognostic and predictive biomarkers of therapeutic targets in
  • colon cancer.
  • To consolidate the CTC (circulating tumour cell) platform in breast and colon cancer, and
  • To develop it in other tumours such as lung and prostate.
  • To continue to be a leading group within the Research Network of Cancer Centres (RTICC) of the Instituto Carlos III.

Lines of research

  • Identification of predictive response factors and new therapeutic targets in colon, breast, glioma, and prostate cancer and design and analysis of the efficacy of new therapies in preclinical models of these tumours.
  • Pharmacogenomic study of predictive factors of response and toxicity in colon, breast, and lung cancer. Analysis of global gene expression. Study of molecular pathological, pharmacodynamic, and pharmacogenetic determinants.
  • Liquid biopsy and biomarkers: a) Biomarkers in liquid biopsy (circulating nucleic acids, circulating tumour cells, vesicles) in cancer patients. Potential use as non-invasive prognostic and predictive biomarkers; b) Mechanistic analysis of circulating nucleic acids in vesicles in the tumour environment, and their influence on tumourigenic processes.
  • Molecular mechanisms of genetic susceptibility to cancer (breast-ovarian syndrome and Lynch syndrome).
  • Microarray and microRNA platform.

Other members of the group

  • Virginia Acedo Jimenez
  • Carlos Aguado De La Rosa
  • María Del Rosario Alfonso San Segundo
  • David Alonso Prieto
  • Inmaculada Bando Polaino
  • Patricia Barreiro Sanabria
  • Julia Barrios Barriga
  • Inés Bartolomé Asensio
  • Jorge Bartolomé Arcilla
  • Javier David Benitez Fuentes
  • Alberto Benito Martín
  • Sara Cañas Herrera
  • Santiago Cabezas Camarero
  • Susana Campuzano Ruiz
  • Laura Carrasco Sánchez
  • Antonio Casado Herráez
  • Isabel Casado Fariñas
  • Mª De Los Angeles Ceron Nieto
  • Marco Ciappara Paniagua
  • Belén Cobaleda Esteban
  • Ana María Colino Gallardo
  • Juan Antonio Corona Sánchez
  • José Antonio Cortés Toro
  • Cristina Díaz-Tejeiro Rodríguez
  • Miguel De La Hoya Mantecón
  • Montserrat De La Torre Serrano
  • David De Pablo Velasco
  • Paula Diaque García
  • Cristina Diaz Del Arco
  • Ada Esteban Sánchez
  • Lorena Fernandez Montarroso
  • María Jesus Fernandez Aceñero
  • Raquel Fernandez Blanco
  • María Begoña Ferrer Meseguer
  • Carlos Alfredo Fraile Olivero
  • Jesús Fuentes Antrás
  • Alicia Fuentes Martín
  • Alicia Gómez Sanz
  • Mª Isabel Galante Romo
  • José Ángel García Sáenz
  • Beatriz García Paredes
  • Vanesa García Barberán
  • Ricardo García Martínez
  • Alicia García Montes-Jovellar
  • Laura García Bravo
  • Gabriel Garcia Salamero
  • Dolores Garcia Lopez
  • Pilar Garre Rubio
  • Adrián Garrido Hernández
  • Juan Gomez Rivas
  • José Luís González Larriba
  • Paula González Heras
  • Maria Luisa Gonzalez Morales
  • Sandra Gutiérrez García
  • María Helena Huertas Mondejar
  • Elena López Calzada
  • Miguel López García
  • Alfonso López De Sá Lorenzo
  • Estela Labad Delgado
  • Víctor Lorca Castellanos
  • Gloria Marquina Ospina
  • Miquel Martínez Fontanillas
  • Ana Martínez Rodríguez
  • María Mateos González
  • José Manuel Morales Gómez
  • Jesús Moreno Sierra
  • Ignacio Moreno Pérez
  • María Teresa Moreno Fernández
  • Fernando Moreno Antón
  • Cristina Nieto Jiménez
  • Elena Nuñez González
  • Alberto Ocaña Fernandez
  • Helena Olivera Pérez-Frade
  • Alberto Orta Ruiz
  • Luis Ortega Medina
  • Natalia Pérez Romero
  • Beatriz Pérez-Villamil Salgado
  • Lucía Paniagua Herranz
  • Daniel Parra Corral
  • Jose Manuel Pingarron Carrazon
  • José Carlos Plaza Hernández
  • Javier Puente Vázquez
  • Sara Rafael Fernández
  • Lobna Ramadane Morchadi
  • Enrique Redondo Gonzalez
  • Sandra Rico Galve
  • Raquel Rodríguez Damiano
  • Pablo Rodríguez Olmedo
  • Eva Rodríguez Escudero
  • María Del Carmen Romero Fernández
  • María Carmen Sáez Rodríguez
  • Melchor Saiz-Pardo Sanz
  • Teresa Salas García-Talavera
  • Jesús María Salinas Casado
  • Passio Beatriz Santos Capa
  • Adrián Sanvicente García
  • Javier Sastre Valera
  • Jose Luis Senovilla Perez
  • Alvaro Serrano Pascual
  • Maria Luisa Suarez Solis
  • Laura Torresano Cicuéndez
  • Manuel Gonzalo Vázquez Masedo
  • Marta Vidaurreta Lázaro

Publications

Projects