The Predictive Biomedicine and Translational Research in Respiratory, Cardiovascular, and Metabolic Diseases group is a multidisciplinary group formed by researchers from different areas of knowledge and specialties of Health Sciences (Public Health, Epidemiology, Pneumology, Cardiology, Statistics and Advanced Data Analysis, Biochemistry, Biology, Genetics, Physiology, Pharmacology, Nutrition, etc.) who carry out their research, healthcare and/or teaching activities in different institutions, mainly in the Faculty of Medicine of the Complutense University of Madrid and the Hospital Clínico San Carlos.

The group’s main line of research is based on predictive biomedicine, which is understood as predictive biomedicine based on the identification of clinical predictors and/or early biomarkers of risk, prognosis, and diagnosis of different types of respiratory, cardiovascular, and metabolic diseases, which allow to detect the early presence of the disease, individualise diagnosis, and treatment, and even to establish changes in lifestyle in an individualised and personalised manner. The group has extensive experience in the identification of clinical variables that predict pathology, and genetic and molecular biomarkers, as well as in “networked” storage and analysis using artificial intelligence, related to the metabolisation of different nutrients in the diet, the risk of suffering a disease, what type of physical exercise is best, how cells age or the molecular and cellular mechanisms that can explain how drugs work, etc.

The group is co-directed by Dr. José J. Zamorano León and Dr. Myriam Calle Rubio who have extensive experience in research, with more than 90 published articles, leading as PI different competitive research projects, both public and private, resulting in numerous D1 and Q1 publications, coordination, and participation in different training books in the areas of Cardiology, Pneumology and the effects of Genetics on the risk of diseases, as well as the direction of numerous doctoral theses. The group includes researchers from the Pneumology Department (Dr José Luis Álvarez Sala Walther, Dr Juan Luis Rodríguez Hermosa, Dr. Gianna Vargas Centanaro, Dr. Myriam Calle Rubio), from the Vascular Surgery Service (Dr. Javier Serrano Hernando, Dr. Antonio Martín Conejero, Dr. Guillermo Moñux), from the Otorhinolaryngology Department(Dr. Joaquín Poch Broto, Dr. María Cruz Iglesias Moreno, Dr. Manuel Gómez Serrano) from the Hospital Clínico San Carlos, and the Departments of Public Health and Maternal and Child Health (Dr. José J. Zamorano León, Dr. Rodrigo Jiménez García, Dr. Ana López de Andrés), from the Medicine Department (Dr. Carlos H. Martínez Martínez, Dr. Khaoula Zekri) from the Physiology Department (Dr. Vicente Lahera Juliá, Dr. Natalia de las Heras Jiménez, Dr. Meritxell López Gallardo, Sandra Ballesteros) from the Faculty of Medicine of the Complutense University of Madrid. In addition, different synergies have been established with the University of Castilla La Mancha (Dr. José M. Garcia, Dr. Antonio Segura).

Review

Dr. José Javier Zamorano León holds a Licentiate degree in Biochemistry from the Complutense University of Madrid. He holds a PhD degree from the Faculty of Medicine, Complutense University of Madrid. He holds a Master’s degree in Public Health from the European University.
He is currently a Professor at the Faculty of Medicine of the Complutense University of Madrid and co-director of the Applied Clinical and Technological Innovation Classroom of the Faculty of Medicine of the Complutense University of Madrid.

He is an active researcher, author of more than 70 publications, 65 of them being original articles in high impact international journals, author of the book “Los Genes de la Nutrición y el Deporte” and 9 chapters of national and international books, more than 75 conference papers, and has participated in 24 research projects.
He is currently the principal investigator of several live projects, notably a FIS project, and a project funded by Bayer AG.
So far, he has supervised 5 doctoral theses, 12 TFG/TFM and has been invited to give 21 lectures in national and international forums.
He is a reviewer in evaluation processes of the FIS Programme for the State Research Agency and the Directorate of Evaluation and Accreditation of the Andalusian Agency of Knowledge in Health Sciences R&D&I Area.

Dr. Miriam Calle Rubio holds a Licentiate degree in Medicine and Surgery from the Faculty of Medicine of the Universidad Autónoma de Madrid.
She is Specialist in Pneumology from the General University Hospital “Gregorio Marañón”.

She is currently Head of Section of the Pneumology Department, Hospital Clínico San Carlos y Associate Professor of Medicine of the UCM.

She is currently a member of the Steering Committee for Integrated Research Projects (IRP) in COPD of SEPAR.
She is the coordinator of the emerging COPD research group of SEPAR. APP Prevexair Project (2010-2016)
Coordinator of the Autonomous COPD Forum of SEPAR. EPOCONSUL project (2015 and 2022) and CONOCEPOC (2011 and 2020) project.
Total IF: 372.82, Total no. of citations: 3460, H index: 35 and Research Gate Score: 39.26.