Brain Glucose Sensors, Control of Satiety, Obesity and Type 2 Diabetes

Strategic objectives

  • To study the role of the metabolic sensor PASK in adaptation to nutritional changes, analysing its role in glucose and lipid metabolism.
  • To study the role of PASK and other metabolic sensors in thermogenesis. To analyse the hypothalamus-brown adipose tissue intercommunication
  • To study possible links between insulin resistance, glucose hypometabolism, and neurodegenerative diseases.
  • To analyse brain glucose metabolism and insulin resistance in animals with tauopathy.
  • To identify mutations associated with the monogenic diabetes MODY and study the regulation of the proteins involved.

Lines of research

  • Studies of the relationship between insulin resistance and neurodegenerative diseases at the molecular level and with PET imaging. Treatment with insulin sensitising agents (metformin and pioglitazone).
  • Expression of brain glucose hypometabolism and insulin resistance in tauopathy transgenic mice.
  • Effect of GLP-2 on proliferation and apoptosis of rat astrocyte cultures.
  • Studies of the role of the PASK sensor in central and peripheral adaptation to: fasting/feeding states, high-fat diets, altered redox states, and ageing.
  • Study of the role of metabolic sensors in the regulation of thermogenesis. Hypothalamus-brown adipose tissue intercommunication
  • Molecular diagnosis of monogenic diabetes MODY and study the regulation of the proteins involved.

Other members of the group