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IdISSC Research Seminar – April’23

12 April 2023

13:00h

Expression of cytokines, adipokines and mRNAs in gestational diabetes. Modification with Mediterranean diet.

Dra. Johanna Josefina Valerio Deogracia

Researcher in the Endocrinology of Metabolic Diseases research group. Health Research Institute of the Hospital Clínico San Carlos (IdISSC).

Dra. Ana Barabash Bustelo

Researcher in the Endocrinology of Metabolic Diseases research group. Health Research Institute of the Hospital Clínico San Carlos (IdISSC).

Summary

An intervention based on a Mediterranean Diet (MedDiet) supplemented with extra virgin olive oil and nuts has been shown to reduce the incidence of Gestational Diabetes Mellitus (GDM) [1,2]. There is growing interest in finding new markers with potential diagnostic and therapeutic utility in GDM. Among these markers are microRNAs related to the glucose pathway, cytokines and adipokines [3].

The aim of our study was to investigate whether there is a serum profile of circulating adipokines, cytokines and miRNAs (miR-222-3p, miR-103a-3p, miR-29a-3, miR-132-3p) related to the occurrence of GDM and glucose regulation at 2-3 years postpartum and whether this profile can be modified by a nutritional intervention based on the Mediterranean diet.

Serum samples from 313 pregnant women from the gestational diabetes prevention study carried out at the Endocrinology Department of the Hospital Clínico San Carlos were used. We compared 77 with GDM versus 236 with normal glucose tolerance (NGT), 141 from the control group (CG, MedDiet restricting dietary fat intake including EVOO and nuts during pregnancy) versus 172 from the intervention group (IG, MedDiet supplemented with extra virgin olive oil (EVOO) and pistachios during pregnancy) at 8-12 weeks’ gestation (visit 1), at 24-28 weeks’ gestation (visit 2) and at 2-3 years postpartum (visit 3). Women with GDM vs. NGD had significantly higher leptin levels [median (Q1-Q3)] [14.6 (9.2-19. 4) vs 9.6 (6.0-15.1) ng/mL; p

Bibliographic reference

  • Assaf-Balut, C.; García De La Torre, N.; Durán, A.; Fuentes, M.; Bordiú, E.; Del Valle, L.; Familiar, C.; Ortolá, A.; Jiménez, I.; Herraiz, M.A., et al. A Mediterranean diet with additional extra virgin olive oil and pistachios reduces the incidence of gestational diabetes mellitus (GDM): A randomized controlled trial: The St. Carlos GDM prevention study. PLOS ONE 2017, 12, e0185873, doi:10.1371/journal.pone.0185873.
  • de la Torre, N.G.; Assaf-Balut, C.; Jimenez Varas, I.; Del Valle, L.; Duran, A.; Fuentes, M.; Del Prado, N.; Bordiu, E.; Valerio, J.J.; Herraiz, M.A., et al. Effectiveness of Following Mediterranean Diet Recommendations in the Real World in the Incidence of Gestational Diabetes Mellitus (GDM) and Adverse Maternal-Foetal Outcomes: A Prospective, Universal, Interventional Study with a Single Group. The St Carlos Study. Nutrients 2019, 11, doi:10.3390/nu11061210.
  • Valerio, J.; Barabash, A.; Garcia De La Torre, N.; De Miguel, P.; Melero, V.; Del Valle, L.; Moraga, I.; Familiar, C.; Durán, A.; Torrejón, M.J., et al. The Relationship between Serum Adipokines, miR-222-3p, miR-103a-3p and Glucose Regulation in Pregnancy and Two to Three Years Post-Delivery in Women with Gestational Diabetes Mellitus Adhering to Mediterranean Diet Recommendations. Nutrients 2022, 14, 4712, doi:10.3390/nu14224712.

13:30 h

Results associated with the research projects of the Medical Physics Service in Interventional Procedures:

Dose recording systems in interventional procedures. Evolution of the DOLQA system from its inception to the present day.

Dr. José Miguel Fernandez Soto

Head of the Medical Physics Department of the Hospital Clínico San Carlos de Madrid. Health Research Institute of the Hospital Clínico San Carlos (IdISSC). Associate Professor CCSS of the Department of Radiology at the Complutense University of Madrid.

Establishment of Patient Dose Reference Levels for fluoroscopy-guided interventional procedures in interventional radiology and interventional cardiology. Results of the MEDICI project.

Prof. Dr. Eliseo Vañó Carruana

Emeritus Professor of the Department of Radiology at the Complutense University of Madrid. Head of the Medical Physics Research Group of the Health Research Institute of the Hospital Clínico San Carlos (IdISSC).

Development of prototype models and skin dose calculation models for patients undergoing skin dose calculations in fluoroscopy-guided interventional procedures in interventional radiology and interventional cardiology.

Dr. Roberto Mariano Sanchez Casanueva

Specialist in the Medical Physics Department of the Hospital Clínico San Carlos de Madrid. Health Research Institute of the Hospital Clínico San Carlos (IdISSC). Associate Professor CCSS of the Department of Radiology at the Complutense University of Madrid.

Virtual mode: https://madrid.zoom.us/j/82112222618https://madrid.zoom.us/j/82112222618?pwd=cUdQT0xveFlYVERCSXVtZkZFMU1PQT09

Classroom: Aula Fernández Cruz of the teaching pavilion of the Hospital Clínico San Carlos.

Contact mail: fibgestor.hcsc@salud.madrid.org